Question
I have lupus and sjogren syndrome started on remicade and now are going every month. It was working but last month they increased my dose and this has made me back to square one-pain and tried all the time. I know I have to be on mtx at the same time but it make me more tired-so I stopped it for the other months and restarted this month-but only did it one time. Could I be rejecting the remicade now. They told me that could happen. On the lower dose I had great engery and felt great -little pain and stiffness-Should I ask to go back to the lower dose?
Answer
It is possible that you have developed a resistance to Remicade. In some case this is due to your immune system making blocking antibodies against Remicade. Taking methotrexate prevents this. It is unlikely that the higher dose is less effective than the lower dose. Talk to your rheumatologist about increasing the dose further or switching to another medication.
