…and rapid clearance in vivo. IL-1 (like IL-4 and IL-6) uses a complex multi-component receptor system in which IL-1 binds with low affinity to the first receptor component (IL-1receptor type…
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Ana-Maria Orbai, MD, MHS
…in inflammatory arthritis. Dr. Orbai was involved in developing the 2012 Systemic Lupus International Collaborating Clinics (SLICC) classification criteria for systemic lupus erythematosus with Dr. Michelle Petri in the Johns…
Targeting Interleukin-17 Studied in Rheumatoid Arthritis
…the most common treatment-related adverse events. In Part B, adverse events were uncommon –with leukopenia being the most common and observed in 7%. Neutrophil counts <1,500 were observed in 5…
Does early treatment of rheumatoid arthritis produce long-lasting benefits?
…first year with use of DMARD therapy in early rheumatoid arthritis compared to the pyramid approach is not sustained if aggressive DMARD therapy is not maintained. Editorial Comments: At first…
Osteoporosis Fracture Management
…the injury. The management of vertebral compression fracture is evolving. Vertebroplasty is FDA approved for the management of pain and physical deformity that result from chronic vertebral compression fracture. Studies…
Risk of Cardiovascular Events Associated with Selective COX-2 Inhibitors News Summary from Johns Hopkins Arthritis
…Mukherjee et al (JAMA 286:954-959, 2001) reviewed several recent published reports on COX-2 agents, as well as data submitted to the US Food and Drug Administration by pharmaceutical companies. The…
