…with complete ankylosis met the primary efficacy endpoint, compared to none of the five subjects in the placebo group. In analyses stratified by HLA-B27 status, there was no statistically significant…
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High Disease Activity During Pregnancy Associated with Lower Birth Weight
…RA group compared to comparison cohorts. Caesarian delivery was more frequent in women with moderate to high RA disease activity during the third trimester compared to women with low disease…
Ability of the PTPN22 1858C/T SNP to Predict RA Development
…is associated with RA. The risk of developing RA is significantly associated with PTPN22 T variant carriage, particularly when in combination with anti-CCP antibodies. Editorial Comment This is an interesting…
Vertebroplasty not Superior to Placebo for the Treatment of Painful Osteoporotic Fractures
…Editorial Comment The results of these two studies are quite astonishing and question the use of a procedure that has become commonplace, albeit with little prior rigorous evaluation. Prior studies…
Association Between Estrogen and COX-2 in Protection from Atherosclerosis
…women. Though this relationship has not been confirmed in humans, recent high profile evidence of increased cardiovascular events associated with several commercially available COX-2 inhibitors is compelling, though sub-analyses by…
Impact of Shared Epitope Genes and Smoking on Risk of Seropositive RA Development
…and 246 men) completed questionnaires concerning smoking habits. 66% of RA patients were seropositive for RF near the time of diagnosis. 1,048 controls (736 women and 312 men) completed questionnaires…
