…I; IL-1RI) and then recruits a second receptor component (IL-1R accessory protein; IL-1RAcP). The complex formed by these two receptor domains (IL1-RI and IL-1RAcP) binds IL-1 with substantially higher affinity…
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Glucosamine and/or Chondroitin Not Effective at Reducing Radiographic Progression of Osteoarthritis of the Knee
…on radiographic progression over 2 years from the same trial (Arthritis Rheum 2008; 58(10): 3183). Methods The Glucosamine/Chondroitin Arthritis Intervention Trial (GAIT) enrolled men and women > 40 years of…
Fibromyalgia – Treatment
…S.G., Bennett, R.M. Pharmacological therapies in fibromyalgia. Best Practice & Research Clinical rheumatology17:611-627, 2003. Busch, A., Schachter, C.L., Peloso, P.M., & Bombardier, C. (2002). Exercise for treating fibromyalgia syndrome. The…
Ratio of serum Osteoprotegerin and RANKL predicts radiographic progression in RA
…ESR levels (r = 0.44 and 0.50, respectively; p <0.001 for both). Significant negative correlation with 5-year radiographic progression was found with the ratio of OPG to RANKL (r =…
Association Between Estrogen and COX-2 in Protection from Atherosclerosis
…cells. Here, Egan et al (Science 306:1954, 2004) examine the putative effects of estrogen on the regulation of COX-2 and subsequent production of atheroprotective prostacyclin. Methods and Results: LDL receptor…
High rates of continuation for RA patients switched to second TNF inhibitor
…of age), with a greater proportion of males (58% vs. 31%), Caucasians (88% vs. 49%), and a higher mean body mass index (BMI) (31.5 vs. 29.5). Baseline chondrocalcinosis was more…