…examining the effect of risedronate on symptoms, radiographic progression, and biomarkers of cartilage degradation in symptomatic medial compartment knee OA., Methods The study was conducted at 42 centers in North…
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Association Between Estrogen and COX-2 in Protection from Atherosclerosis
…women. Though this relationship has not been confirmed in humans, recent high profile evidence of increased cardiovascular events associated with several commercially available COX-2 inhibitors is compelling, though sub-analyses by…
Anti-TNF Therapy for Rheumatoid Arthritis
…a complete list. For complete list of TNF ligands and receptors, and updated nomenclature, see reference 4. In contrast to the relatively restricted synthesis of TNF-aby macrophages and T cells,…
Are the Incidence and Prevalence of RA Changing in the United States?
…after diagnosis. Compared to prior periods, smoking in men, but not women, had decreased from the 1985-1994 period. The demographic adjusted incidence rate for RA was 41 per 100,000 (95%…
CTLA4Ig Shows Promise in the Treatment of RA
…be considered high, despite concurrent methotrexate. Eighty patients discontinued the study prior to completion, half of whom were from the placebo group. Most discontinued because of lack of efficacy. The…
In Crohns disease, the development of antibodies to infliximab (Remicade) is associated with shorter duration of clinical response and more infusion reactions.
…evaluated before and after each infusion. Concentrations of infliximab and antibodies to infliximab were assayed at each visit and before each infusion by commercial ELISA. Concentrations of infliximab below 1.4…