…study (n=217 placebo subjects (69%) and n=206 CS subjects (67%)). Women comprised 68% of enrolled subjects with a mean age of 62 years. Most (57%) of subjects had advanced (Kellgren/Lawrence…
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Risk of Cardiovascular Events Associated with Selective COX-2 Inhibitors News Summary from Johns Hopkins Arthritis
…resuscitated cardiac arrest, sudden or unexplained death, ischemic stroke, and transient ischemic attack) with rofecoxib treatment compared with naproxen was 2.38 (95% confidence interval, 1.39-4.00; p=.002). There was no significant…
Excercise and Osteoarthritis
…OA, most knees with incident knee OA were symptomatic (80.4%), and most showed OA in the tibiofemoral compartment (84.1%). Walking for Exercise Regular walking for exercise was reported in 48%…
Ability of the PTPN22 1858C/T SNP to Predict RA Development
…PTPN22 T variant to identify a pre-RA patient (sensitivity) was 39.3%, which was more sensitive than IgG RF (16.9%) or IgM RF (22%), of comparable sensitivity to anti-CCP antibodies (37.1%),…
Risedronate not an Effective Disease Modifier in Knee Osteoarthritis
…mm of joint space width (JSW)) were randomized in a double-blind fashion to receive risedronate 5 mg/day, 15 mg/day, 35 mg/week (Europe), 50 mg/week (North America), or placebo for 2…
Is There an Increased Risk of Malignancy and Serious Infection Among RA patients Receiving High-dose Anti-TNF Therapy?
…were omitted (OR 4.5 (95% CI 1.3 15.8)) or if non-melanoma skin cancers were omitted (OR 3.7 (95% CI 1.0 13.2)). When stratified by dose of TNF inhibitor, high-dose therapy…