The advent of the new biologic therapeutic agents in recent years has increased the concern for opportunistic infections that complicate rheumatoid arthritis (RA). In comparison to the general population, mortality…
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Long-term structural benefits from short-term aggressive treatment of early rheumatoid arthritis
…that treatment with combinations of DMARDs is superior to treatment with sequential single DMARDs in suppressing disease activity and slowing destruction of the joints. One such report from the Combinatietherapie…
Arthritis Research
…is often marked by flares and remissions or times when symptoms are more pronounced, then dissipate. Common complaints are joint pain and generalized stiffness throughout the day, joints that may…
Decorin Deficient Mice Show Resistance to Lyme Disease News Summary from Johns Hopkins Arthritis
…dissemination of Borrelia in joints, heart, bladder and ear tissues. The percent of positive cultures for Borrelia was significantly reduced in Dcn -/- mice compared to Dcn +/- and Dcn…
Transcription of several genes associated with antigen-induced anergy are regulated by rheumatoid arthritis synovial T cells News Summary from Johns Hopkins Arthritis
…compared to an anergic T-cell clone and to T-cells from reactive arthritis (ReA) patients in which no activation defect is known. Transcription of anergy-related transcripts was compared in synovial tissue…
Intraarticular Injection of Infliximab not Effective in Patients with Inflammatory Arthritis
…effective. In total, none of the 20 injections of infliximab were deemed effective, compared to 8 of the 21 injections of methylprednisolone (38%; p=0.004 compared to infliximab). Time to failure…
