The advent of the new biologic therapeutic agents in recent years has increased the concern for opportunistic infections that complicate rheumatoid arthritis (RA). In comparison to the general population, mortality…
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Comparison of Febuxostat and Allopurinol on Serum Urate Levels
Study results by Moreland, et al comparing febuxostat with allopurinol in Patients with hyperuricemia and gout are now published (N Engl J Med 353: 2505-2507). In this multicenter study, 760…
No Link Between RA Therapy and Lymphoma Observed in Large Cohort of Rheumatoid Arthritis Patients
…techniques used to account for non-random treatment assignment are an advantage of this study compared to other observational studies, they cannot completely control for the effect of confounding by indication….
FDA APPROVED: Subcutaneous Abatacept for the Treatment of Rheumatoid Arthritis
…double-blind, double-dummy study; therefore patients in both groups received subcutaneous or intravenous placebo, as appropriate. The study was powered to be a non-inferiority comparison. The primary endpoint was ACR 20…
Predictors of Increased Carotid Atherosclerosis in RA Patients
…carotid plaque in individuals with RA compared to non-RA controls. Here, Roman et al. (Ann Intern Med 2006; 144:249) confirm this risk for the first time. Methods Adult RA patients…
Swefot Trial Suggests Adding TNF Inhibitor Better than Triple Therapy in RA Patients who do not Rapidly Respond to Methotrexate
…the goal and 2) it suggests that a TNF inhibitor should be chosen over combination non-biologic DMARD therapy in patients who fail initial methotrexate combination therapy. The study does not,…