…Weighing the Options: Criteria for Evaluating Weight-Management Programs. Washington,D.C., National Academy Press; 1995. References Creamer P, Hochberg MC: Osteoarthritis. Lancet 1997;350:503-508. Felson DT: Weight and osteoarthritis. J.Rheumatol. 1995;43:7-9. Carman WJ,…
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Estrogen Deficiency Induces Bone Loss by Enhancing T Cell Production of TNF alpha news summary by Johns Hopkins Arthritis
…resorption. Activated T cells also induce osteoclast formation contributing to inflammation-induced bone loss. Since T cells express estrogen receptors, Cenci, et al (J Clin Inv 106:1229, 2000) have investigated the…
CTLA4Ig Shows Promise in the Treatment of RA
…(n=115) ACR 20 35.3% 41.9% 60.0% (P<0.001) ACR 50 11.8% 22.9% (P<0.05) 36.5% (P<0.001) ACR 70 1.7% 10.5% (P<0.05) 16.5% (P<0.001) Other efficacy endpoints, measured through the SF-36 questionnaire, showed…
Intraarticular Injection of Infliximab not Effective in Patients with Inflammatory Arthritis
FDA APPROVED: Subcutaneous Abatacept for the Treatment of Rheumatoid Arthritis
…76.0% (95% CI 72.9, 79.2) for the group receiving subcutaneous abatacept and 75.8% (95% CI 72.6, 79.0) for the group receiving intravenous abatacept. Similarly, the ACR 50 and 70 responses…
In Crohns disease, the development of antibodies to infliximab (Remicade) is associated with shorter duration of clinical response and more infusion reactions.
…categorized as follows: 1) negative if < 1.69 g/ml and [infliximab]<1.4 g/ml; indeterminate if < 1.69 g/ml but [infliximab] > 1.40 g/ml; and, positive if > 1.69 g/ml and [infliximab]…