…In the past, the outcome criteria used in clinical trials to determine the effectiveness of new agents has varied making the comparison between agents and between clinical trials difficult. Two…
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Reduced Disability at Five Years with Early Treatment of Inflammatory Polyarthritis News Summary from Johns Hopkins Arthritis
…data support the notion that early aggressive treatment is associated with better functional outcomes at 5 years. The propensity score was used to adjust for “confounding by indication”. Editorial Comment:…
Pfizer Releases Statement on Cardiovascular Safety of Celecoxib (Celebrex)
…and non-fatal cardiovascular events compared to patients receiving placebo. Based on this review, dosing of celecoxib was halted for this trial. An identical review by the same DSMB of the…
FDA Arthritis Advisory Board Recommends the Approval of Tocilizumab (Actemra) for the Treatment of RA
Figure: Tocilizumab prevents binding of IL-6 with its receptor On July 29, 2008, the Arthritis Advisory Board of the FDA reviewed the new Biologics License Application for tocilizumab, which will…
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Genentech announces information regarding Rituximab and a Rare Opportunistic Infection
…occurrence of two cases of progressive multifocal leukoencephalopathy (PML), a rare opportunistic infection of the central nervous system (CNS), in two patients receiving the drug for treatment of major complications…