…IgG1, works by binding CD80 and CD86 on antigen presenting cells. Preventing this binding blocks the engagement of CD28, a sequence of co-stimulatory events required for optimal activation of T…
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Are the Incidence and Prevalence of RA Changing in the United States?
…after diagnosis. Compared to prior periods, smoking in men, but not women, had decreased from the 1985-1994 period. The demographic adjusted incidence rate for RA was 41 per 100,000 (95%…
Risk of Recurrent Gastrointestinal Bleeding in Patients Taking Celecoxib
…for ulcer complications, treatment with celecoxib is as effective as treatment with diclofenac plus omeprazole at preventing recurrent gastrointestinal bleeding. Renal adverse events are common with both treatment regimens. Editorial…
FDA APPROVED: Subcutaneous Abatacept for the Treatment of Rheumatoid Arthritis
…were comparable between the two groups. The proportion of patients in each group with improvements in HAQ-DI was comparable (68.2% subcutaneous vs 63.8% intravenous). The safety profile was also similar…
Are TNF Inhibitors Efficacious for the Treatment of Sciatica?
…Conclusions Compared to placebo, two injections of adalimumab improved back pain, reduced the need for surgery, and (to a smaller extent) reduced leg pain associated with acute sciatica. Editorial Comment…
Disease Outcomes of Early Non-Radiographic Spondyloarthropathy Explored
…age of onset did not differ according to whether the patient has AS or non-radiographic SpA. Conclusions Compared to those with AS of comparable disease duration, those with non-radiographic SpA,…