Home > Arthritis News > 1999 Arthritis News – 1999 Lyme disease is a tick-borne infection caused by Borrelia burgdorferi. Manifestations include arthritis, cardiac effects, neurologic abnormalities, and secondary skin…
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What Effect Does BMI Have on Mortality in Patients with Rheumatoid Arthritis
…of 3460 patient-years. 71% of patients were female. At intake, 38 (5%) were classified as underweight (BMI < 20), 195 (25%) were normal weight (BMI of 20 to <25), 264…
Osteoarthritis: Pathophysiology
…levels of the cartilage proteoglycan aggrecan, implications for pathogenesis. J Clin Invest 94:25-33, 1994 Woessner Jr. MF, Gunja-Smith Z., Role of metalloproteinases in human osteoarthritis. J Rheumatol 18;99-101, 1991 Lotz…
Interleukin-18 Acts as a Proinflammatory Stimulus in Rheumatoid Arthritis
…explanation is over expression of interleukin-18 (IL-18). IL-18 exhibits synergy with IL-12 in promoting Th1 responses, induces proliferation, upregulates IL-2R a expression, and promotes TNF-a, and GM-CSF production by Th1…
Johns Hopkins Arthritis News on Increased Risk of Subsequent Osteoarthritis in Individuals with Previous Joint Injury
…clinical (and radiological, where available) criteria. Overall, 141 participants reported a joint injury during adolescence or young adulthood (knee alone, n=111; hip alone, n=16; injuries at both sites, n=14). Of…
Osteoarthritis: Signs and Symptoms
…beginning (because symptoms become worse with use / activity). SIGNS / EXAM FINDINGS: Physical findings in osteoarthritic joints include bony enlargement, crepitus, cool effusions, and decreased range of motion. Tenderness…