Severe Medial Compartment Knee OA The efficacy of glucosamine and/or chondroitins in knee osteoarthritis (OA) has been controversial. A recent large, randomized, multicenter trial (the GAIT trial) found no symptomatic…
Search Results for: osteoarthritis
Excercise and Osteoarthritis
Exercise may decrease the risk of developing knee osteoarthritis (OA) via trophic effects on cartilage and muscle strengthening. However, exercise may also predispose to knee OA via joint loading and…
Risedronate not an Effective Disease Modifier in Knee Osteoarthritis
Despite its prevalence, no effective pharmacotherapies have been definitively proven to modify the course of radiographic knee osteoarthritis (OA). Risedronate, a bisphosphonate that reduces bone turnover, has been shown in…
Arthroscopic Surgery is No Better than Placebo (Sham Surgery) in Treating the Pain and Dysfunction of Osteoarthritis of the Knee
As osteoarthritis (OA) of the knee progresses in severity, the pain can become refractive to medical therapies such as acetaminophen and nonsteroidal anti-inflammatory medications, and intra-articular injections of corticosteroids and…
Constitutive Expression of Human Collagenase-3 (MMP-13) Induces Osteoarthritis-like Illness in Mice
Constitutive Expression of Human Collagenase-3 (MMP-13) Induces Osteoarthritis-like Illness in Mice An increasing body of evidence has pointed to a major role for matrix metalloproteinase (MMP-13) in the degradation of…
Glucosamine and/or Chondroitin Not Effective at Reducing Radiographic Progression of Osteoarthritis of the Knee
Figure: Molecular Structure of Glucosamine Glucosamine, with or without chondroitin, is a popular and high selling neutraceutical with claims to improve symptoms associated with painful osteoarthritis (OA). Clinical trials testing…