…and at 6 and 18-months by the Medical Outcomes Study Short-Form 36 Health Survey (SF-36). Results: Each intervention produced weight loss: diet-only (5.7% of body weight), exercise-only (2.6%), diet and…
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Possible new role for NF-kB in the resolution of inflammation
…was reduced by 26% (P<0.001). However, when given at 24 hours, PDTC lengthened the inflammatory response and led to a seven-fold increase in exudate volume and a 2.3-fold increase in…
Effects of conventional NSAIDs, selective COX-2 and COX-1 inhibitors on premature labor and closure of the ductus arteriosus in mice
…efficacious in delaying on the onset of premature labor (induced by lipopolysaccharide). COX-1 inhibition also delayed onset of labor in full-term pups. Conclusion: Selective COX-1 inhibition, but not COX-2 inhibition,…
Vasoactive intestinal peptide (VIP) prevents experimental arthritis News Summary from Johns Hopkins Arthritis
…the CD4:CD8 ratio in synovium; suppression of inflammatory cytokines (e.g., tumor necrosis factor and interleukin-1) and upregulation of anti-inflammatory cytokines (e.g., interleukin-10 and interleukin-1 receptor antagonist); suppression of MMP-2 gelatinase…
Inhaled Glucocorticoids Leads to Dose-Related Bone Loss in Premenopausal Women News Summary from Johns Hopkins Arthritis
…glucocorticoid therapy during the study. There was no dose-related effect found at the femoral neck or the spine. Editorial Comment: Osteoporotic fractures are a well documented problem in post-menopausal women…
A Reappraisal of HAQ Disability in Rheumatoid Arthritis (RA)
…prospective, long-term study of disability in RA. Methods: The course of HAQ disability was assessed in 32,525 observations (1,843 patients) in which the HAQ was administered. In addition, the course…