…an inflammation-inducible promoter was developed. A two-component inflammation-inducible expression system was used. In the construct, the promoter region of the complement factor 3 (C3) acute-phase protein regulated the expression of…
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Incidence of antibodies to double-stranded DNA following treatment with infliximab (Remicade) Arthritis News Summary from Johns Hopkins Arthritis
…treatment with infliximab and from 37 patients treated with placebo infusions were tested for anti-dsDNA antibodies by three methods: 1) Crithidia lucilae indirect immunofluorescence test (CLIFT); 2) a commercial Farr…
Effect of Improving Depression on Pain and Function in Older Adults with Arthritis
…of life in older adults with arthritis. Editorial Comments: This study provides support for providing specific and focused depression care in older adults with co-existing arthritis. That is, the effect…
Bone Marrow Lesions are Associated with Pain in Knee Osteoarthritis News Summary from Johns Hopkins Arthritis
…asked to complete a visual analogue scale for pain and to fill out the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). These scores were used to assess severity of…
Effect of Rofecoxib on Renal Function is Similar to Nonselective NSAIDS
…COX-2 selective drug, rofecoxib, has effects on renal function that are similar to nonselective NSAIDs. Therefore, rofecoxib should be used cautiously in patients at risk for renal insufficiency. Editorial comment:…