…days for two weeks. Results: Mice treated with VIP showed delayed onset, lower incidence and decreased severity of CIA in comparison with placebo-treated arthritic mice. Histologically, there was profound reduction…
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Osteoarthritis: Differential Diagnosis
…joint suggests a crystalline etiology. Arthrocentesis (aspiration of the joint) can help aid in distinuishing between these types of arthritis if the diagnosis is not clear by history, physical exam,…
Osteoarthritis: Signs and Symptoms
…disease. Stiffness in the morning or following inactivity (“gel phenomenon”) rarely exceeds 30 minutes. Patients have pain which is generally worse at the end of the day compared to the…
Incidence of TB in TNF-Treated and TNF-Untreated Patients
…of any infection in TNF inhibitor treated patients. Using a different data collection instrument, the National Data Bank for Rheumatic Diseases, Wolfe et al (Arthritis Rheum 50(2):372, 2004) examine the…
Osteoarthritis: Pathophysiology
…compressive properties which are imparted by its extracellular matrix, composed predominantly of type II collagen and proteoglycans. Under normal conditions, this matrix is subjected to a dynamic remodeling process in…
NF-kb and C-Rel Transcription Factors Have Distinct Roles in Inflammatory Arthritis
…plays a critical role in immune regulation, nonspecific inhibition might compromise normal host defenses. An alternative approach is to identify and target only the Rel/NF-kB subunits that are critical for…