High incidence of cardiovascular events in Rheumatoid Arthritis cohort not explained by traditional risk factors Patients with rheumatoid arthritis (RA) have a shortened lifespan compared to age- and gender-matched controls….
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Cytokine Traps: Novel Anti-Cytokine Blockers
…and rapid clearance in vivo. IL-1 (like IL-4 and IL-6) uses a complex multi-component receptor system in which IL-1 binds with low affinity to the first receptor component (IL-1receptor type…
European Admixture Associated with Genetic Risk for Rheumatoid Arthritis in African-Americans
…Of these, 42% had at least one SE allele, compared to 25% of African American control subjects (p=0.0004). The frequencies of the *0401, *0404, *0405, and *1001 SE alleles were…
Swefot Trial Suggests Adding TNF Inhibitor Better than Triple Therapy in RA Patients who do not Rapidly Respond to Methotrexate
Initial combination therapy has been shown to be superior to step-up combination therapy in groups of RA patients; however, these findings are difficult to reconcile with the observation that many…
Leflunomide and Pregnancy Outcomes Explored
…mother was electively terminated. Among the live births, delivery by cesarean section was significantly more common among leflunomide exposed mothers (48%) compared to disease-matched non-exposed mothers (29%) or healthy control…
Adalimumab (Humira) in Combination with Methotrexate is Efficacious for Treatment in RA Patients
Adalimumab (Humira) in Combination with Methotrexate is Efficacious for Treatment in RA Patients Weinblatt et al (Arthritis Rheum 48:35, 2003)) evaluate the efficacy and safety of adalimumab in combination with…